Publications

Antigen-experienced memory B cells (MBCs) can take up long-term residency in tissues, yet how B resident memory cells (BRM) are recruited and retained in tissues is not well understood. Tan et al. used a murine influenza infection model to characterize BRM in the lung. Influenza-specific BRM expressed lung residency markers CXCR3, CCR6, and CD69, were located in inducible bronchus-associated lymphoid tissue, and had transcriptional profiles distinct from circulating or splenic MBCs. CCR6 expression on BRM facilitated recruitment, retention, and recall in the lung. Human influenza-specific BRM were also transcriptionally distinct to circulating or lymph node MBCs and highly expressed CCR6 and CXCR3, as well as CD69. These findings demonstrate that influenza infection induces a distinct population of BRM in the lungs of mice and humans