Dr Wen Shi Lee
+61 3 8344 9938
Wen Shi is a postdoctoral researcher in the Kent Laboratory. He was awarded his PhD in 2019 on studies investigating whether antibodies that mediate antibody-dependent cellular cytotoxicity (ADCC) could be utilised for an HIV cure. Wen Shi continues his interest in antibody Fc effector functions and recently began characterising SARS-CoV-2 specific antibodies in people who recovered from COVID-19.
Antibody Fc effector functions
In addition to recognising and neutralising viruses via the antigen-binding fragment (Fab), antibodies can engage innate immune cells via the Fc region and mediate a myriad of effector functions including antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent phagocytosis (ADP).
We recently characterised ADCC and ADP responses in people who recovered from COVID-19 and found that they last longer than neutralising antibodies.
A THP-1 monocyte (blue) forming an immunological synapse with an antibody-coated target cell expressing SARS-CoV-2 spike (red)